The secondary endpoint will be analysed in a similar
manner to the primary endpoints. Tests for interaction
for the colon cancer subgroups and other subgroups
will be conducted. Analyses of primary and secondary
endpoints will be repeated within the subgroups defined
by ethnicity and tumour type. Analysis of primary and
secondary endpoints will also be repeated for compliant
and non-compliant subjects. In addition, cumulative
incidence function will be estimated and the two treatment
arms will be compared using Gray’s method if
competing risks are present