Use, indications and contraindications The spray is simple to apply and requires no specialist training. It has to be applied at every dressing change or at least every third day. No adverse reactions have been reported to date. However, it is not suitable for use with certain disinfectants and proteolysis or mechanical debridement as these will impair its action. Granulox is contraindicated on infected wounds or pregnant/lactating mothers, as insufficient data is available to evaluate these cases. Debridement of necrotic tissue or slough is advised prior to application in order to enable the spray to be applied to non-devitalised tissue.