Study Design.
Fpn fl/fl Myh6.Cre+ mice, Hamp−/− mice, and their respective littermate controls Fpn fl/fl and Hamp+/+ were housed under standard animal housing conditions in individually ventilated cages. They were assessed for cardiac function by cine MRI at age 3 wk, 6 wk, 3 mo, or 6 mo, and then were culled for assessment of systemic and cardiac iron indices.