expression while SREBP-2 to regulate the cholesterogenic
gene expression. It has been reported that elevated
expression of SREBP-1 has been detected in several
cancer types and was closely correlated with malignant
transformation, cancer progression and metastasis [28].
Inhibit the expression of SREBP-1 leaded to impaired
tumor growth [23]. The studies we described here showed
that the expression of SREBP-1 was reduced by GA
treatment in pancreatic cancer cells and hepatocellular
carcinoma cells, however, the expression of SREBP-2
remained unchanged. These results indicated GA may only
have an effect on lipid metabolism and has no effect on
cholesterol metabolism.