]. The adduction of cathepsin B by
PC-HAs in mouse peritoneal macrophages corresponds to a concomitant
reduction in cathepsin B enzyme activity, suggesting that modification
of the cathepsin B by oxPL could reduce the capacity of
macrophages to perform lysosomal degradation of internalized material.
While these initial studies are promising, a more thorough analysis
of HOOA-PC and HODA-PC targets is necessary and could be
achieved by the aforementioned methods using affinity purification
of protein adducts followed by proteomics.