To date, clinical trials evaluating the safety and efficacy of DTG justify its role as first line therapy for treatment-naïve patients infected with HIV. In treatment-experienced patients, the quantity and type of resistance mutations must be considered prior to initiating therapy. Among the INSTIs, DTG has the benefit of once daily administration as in EVG, but with relatively few drug interactions, similar to RAL. Additionally, it offers the only single tablet regimen for patient with or at risk for renal dysfunction. Providers should consider the benefit of sequencing first- and second-generation INSTIs, but this should not preclude the use of DTG in a patient. Lack of significant drug interactions, minimal adverse effects, and the availability of a single tablet regimen make DTG a valuable and viable option for both patients and providers.