Cigarette use frequency and depression symptoms were associated with frequency of marijuana use
(p-values b .001), particularly in adolescence, but there were important gender differences in these relationships.
Specifically, symptoms of depression were related to marijuana use frequency among males (p b .001), but not
females (p=.62). In addition, frequency of marijuana use was associated with increased cigarette use frequency,
especially among males who had higher symptoms of depression (p b .001). However, this effect was not seen
among females. Exploratory analyses suggested that relationships between frequency of use and depression
are specific to marijuana, not cigarettes.