The intragastric administration of 0.6M HCl produced
macroscopically visible hemorrhagic lesion in the glandular
portion of the stomach. The ulcer index of the control
animals was 3.6 ± 0.5 (Fig. 3). Lesion formation was
not significantly modified by higher doses of the extract
(50 and 100 mg/kg). By contrast HCl induced gastric lesion
was significantly reduced by the reference drug, sucralfate
(500 mg/kg) and 25 mg/kg of the extract (Fig. 3). In this
group (25 mg/kg), the ulcer incidence was 40% as compared
to 100% in the other groups (50 and 100 mg/kg).