Honey is an important and unique food product
containing bioactive compounds derived from bees and
plants [20]. Honey is produced from many sources and its
antimicrobial activity. More recently, honey has been
reported to have an inhibitory affect to around 60 species
of gram – positives bacteria and gram – negatives bacteria
[16]. Current evidence suggests that several factors may
contribute to the antimicrobial properties of honey, the
most important being osmolarity, acidity, the enzymatic
generation of hydrogen peroxide and the presence of
various non –peroxide compounds derived from the pollen
or the nectar of flowers [24]. Honey possesses inherent
antimicrobial properties due to high osmotic pressure with
low water activity, in which the low water activity of
honey is inhibitory to the growth of the majority of
bacteria and many yeasts and moulds [17].The resistant
strain, MRSA which is widespread, particularly in the
hospital sitting. S. aureus (MRSA) generally remained an
uncommon finding even in hospital sittings until the
1990s when there was an explosion in (MRSA) prevalence
in hospitals of S. aureus (MRSA) [7].
The moist environment of chronic wounds is an ideal
growth medium for bacteria [21], and infection is the
prominent cause of delayed healing. This has become an
increasing problem with the recent expansion of
antibiotics – resistant bacteria [13]. Burns and chronic
wound are particularly prone to infection with75% of dirty
following burns involving infection [26]. One of the most
emphasized subjects about pathogenesis of Staphylococci
infections is the slime production characteristic [10].
Multi-resistant coagulase-negative Staphylococci (CoNS)
may adhere to medical devices and surfaces through slime