From the above results we concluded that there is a significant relationship between fatty diet intake and structural changes to the brain with the elevated levels of dopamine, BCHE, homocysteine, and the brain damage was associated with increased oxidative stress monitored by increased MDA level whereas GSH and SOD production decreases. These changes may alter testicular functions and consequently it may be speculated that obesity can be an important causative factor in the etiology of the male infertility. While oral administration of Orlistat and herbal mix extracts reduced the level of circulating lipids as well as the decrease of body weights in male albino rats, these extracts improve brain and testes functions.