As a test of calibration, we evaluated the association between PPI exposure and the outcome of AKI. The intent of this analysis was to examine the presence of an association where a prior observations suggest that an association is expected.1–3 The results suggest that patients in the PPI group have an increased risk of AKI (HR, 2.15; 95% CI, 2.00 to 2.32). To examine whether the association of PPI exposure and risk of chronic renal outcomes is mediated by occurrence of AKI, we controlled for AKI occurrence during exposure to acid-suppression therapy. The results suggest that associa- tions remain significant (Table 7).
เราประเมินความสัมพันธ์ระหว่างPPI exposure และthe outcome of AKI.จุดประสงค์ของการวิเคราะห์นี้เป็นการ ตรวจสอบการมีอยู่ของความสัมพันธ์