We are living in a vastly altered world where societal expectations of businesses have changed dramatically. At the cornerstone of the discourses dealing with human resources (HR), corporate social responsibility, corporate governance, and sustainability, are humans—their rights, their aspirations, and advancement. Humans are pivotal to both global corporations‟ survival and the wealth of nations. Nothing can be mobilized and no progress can be achieved in the absence of this essential resource. Never before has the pressure on organizations, to ensure that the basic rights of humans are protected and respected both within them and the communities they operate in, been greater. The purpose of this paper will be to review current worldwide trends and practices of leading corporations (profit and non-profit) in their management of human resources and social responsibility. An examination of the responsibilities of these global corporations will be made, and recommendations for reconciling these dual responsibilities and reshaping global HR practices will be presented.