L-Glu is stored in synaptic vesicles and
released to the synaptic cleft to activate iGluRs and mGluRs for
neurotransmission. The action of L-Glu is terminated by EAATs. In the
glial cell, L-Glu is transformed to L-Gln which is then transported into the
presynaptic neuron where L-Gln is converted to L-Glu and loaded into
synaptic vesicles by VGLUT.