Fourteen children (6 M, 8 F) suffering from refractory epilepsy received LTG as add-on therapy. LTG was administered twice daily at dosages increasing up to 2 mg/kg/day (for patients taking VPA) or to 10 mg/kg/day for patients taking AEDs that induce hepatic metabolism. The drug was withdrawn for side effects in 3 cases (rash: two cases, hirsutism: one), because of increased seizure frequency in 2 cases and because of unchanged seizure frequency in one. One patient died from acute respiratory failure, after repeated respiratory tract infections.
A decrease in seizure frequency after one year of treatment with LTG was observed in 6 of the 7 patients who completed the study. The median total seizure frequency decreased from 10.7 ± 7.3 to 3.8 ± 4.6 seizures per day. At the end of the study, seizure frequency had decreased by more than 50 % in 2 patients, by more than 75 % in 2 patients, and 2 patients were seizure-free; in the remaining patient seizure frequency was unchanged.
The best results were obtained with plasma LTG concentrations ranging from 0.5 to 5.4 µg/ml; no further improvement was observed at higher LTG concentrations.
Fourteen children (6 M, 8 F) suffering from refractory epilepsy received LTG as add-on therapy. LTG was administered twice daily at dosages increasing up to 2 mg/kg/day (for patients taking VPA) or to 10 mg/kg/day for patients taking AEDs that induce hepatic metabolism. The drug was withdrawn for side effects in 3 cases (rash: two cases, hirsutism: one), because of increased seizure frequency in 2 cases and because of unchanged seizure frequency in one. One patient died from acute respiratory failure, after repeated respiratory tract infections.A decrease in seizure frequency after one year of treatment with LTG was observed in 6 of the 7 patients who completed the study. The median total seizure frequency decreased from 10.7 ± 7.3 to 3.8 ± 4.6 seizures per day. At the end of the study, seizure frequency had decreased by more than 50 % in 2 patients, by more than 75 % in 2 patients, and 2 patients were seizure-free; in the remaining patient seizure frequency was unchanged.The best results were obtained with plasma LTG concentrations ranging from 0.5 to 5.4 µg/ml; no further improvement was observed at higher LTG concentrations.
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