Polyalthia debilis (Pierre) FINET & GAGNEP. (Annonaceae), is a Thai medicinal plant whose root
water decoction has been traditionally used for treatment of abdominal pain and tuberculosis, as a
febrifuge and a galactogogue [1]. Previously, isolation of some new antimalarial dimeric aporphines
from the root of P. debilis was reported [2]. To identify additional and new bioactive compounds, the
present study investigated the isolation, antimicrobial, antimalarial and cytotoxic activities of
chloroform and ethyl acetate extracts of P. debilis.