Primary Literature Search: Treatment of T2DM
Thousands of articles were retrieved and considered on the basis of the aforementioned criteria. From those, 199 abstracts were identified for pos- sible inclusion, and 58 were retained for systematic review. Results of the literature review are presented in the following text and listed in the evidence tables in the Supplemental Information.
Of the 58 articles retained for sys- tematic review, 5 studies were classi- fied as grade A studies, 1 as grade B, 20 as grade C, and 32 as grade D. Articles regarding the treatment of T2DM selected for inclusion were di- vided into 4 major subcategories on the basis of type of treatment being dis- cussed: (1) medical treatments (32 studies); (2) nonmedical treatments (9 studies); (3) provider behaviors (8 studies); and (4) social issues (9 stud- ies). Detailed information about these articles is presented in Supplemental Information A. A graphic depiction of the grades of study according to sub- division is given in Table 1.
Rejected Articles
Of the 257 articles meeting search criteria, 199 were rejected, catego- rized as follows:
Comorbidities: 69 studies. (Note: these articles were rejected within the con- text of the primary search string re- lating to treatment of T2DM. A second prospective literature search was conducted solely addressing comor- bidities, the results of which are pre- sented in the next section.)
Medical treatment: 99 articles.
Nonmedical treatment: 16 articles.
Social issues: 12 articles.
Provider behaviors: 3 articles.
To view the recommendations related to management of T2DM, please see the accompanying clinical practice guideline.36
Secondary Literature Search: Comorbidities of T2DM
Evidence is sparse in children and adolescents regarding the risks for
developing various comorbidities of diabetes that are well recognized in adult patients. Numerous reports have documented the occurrence of comor- bidities in adolescents with T2DM, but no randomized clinical trials have ex- amined the progression and treatment of comorbidities in youth with T2DM.29 The evidence that does exist is con- tradictory with regard to both screen- ing and treatment recommendations. After applying the previously described search criteria and screening to thou- sands of articles, an additional 336
Primary Literature Search: Treatment of T2DM
Thousands of articles were retrieved and considered on the basis of the aforementioned criteria. From those, 199 abstracts were identified for pos- sible inclusion, and 58 were retained for systematic review. Results of the literature review are presented in the following text and listed in the evidence tables in the Supplemental Information.
Of the 58 articles retained for sys- tematic review, 5 studies were classi- fied as grade A studies, 1 as grade B, 20 as grade C, and 32 as grade D. Articles regarding the treatment of T2DM selected for inclusion were di- vided into 4 major subcategories on the basis of type of treatment being dis- cussed: (1) medical treatments (32 studies); (2) nonmedical treatments (9 studies); (3) provider behaviors (8 studies); and (4) social issues (9 stud- ies). Detailed information about these articles is presented in Supplemental Information A. A graphic depiction of the grades of study according to sub- division is given in Table 1.
Rejected Articles
Of the 257 articles meeting search criteria, 199 were rejected, catego- rized as follows:
Comorbidities: 69 studies. (Note: these articles were rejected within the con- text of the primary search string re- lating to treatment of T2DM. A second prospective literature search was conducted solely addressing comor- bidities, the results of which are pre- sented in the next section.)
Medical treatment: 99 articles.
Nonmedical treatment: 16 articles.
Social issues: 12 articles.
Provider behaviors: 3 articles.
To view the recommendations related to management of T2DM, please see the accompanying clinical practice guideline.36
Secondary Literature Search: Comorbidities of T2DM
Evidence is sparse in children and adolescents regarding the risks for
developing various comorbidities of diabetes that are well recognized in adult patients. Numerous reports have documented the occurrence of comor- bidities in adolescents with T2DM, but no randomized clinical trials have ex- amined the progression and treatment of comorbidities in youth with T2DM.29 The evidence that does exist is con- tradictory with regard to both screen- ing and treatment recommendations. After applying the previously described search criteria and screening to thou- sands of articles, an additional 336
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