Arterial Elasticity Measurements
Arterial compliance measures were performed after an
overnight fast and before blood sampling. Measures were
performed between 8 and 10 AM, in a quiet, temperature
-controlled laboratory. With the subject in a supine position,
radial arterial waveforms were recorded for 30 sec.
The pressure transducer amplifier system was connected
to a specially designed device (Model CR-2000, Hypertension
Diagnostics Inc. Eagan, MN). The passive transient
response of the arterial vasculature to the initial
loading conditions was determined by analyzing the diastolic
portion of the pressure pulse-wave form. This technique,
which has been validated for its reproducibility
and used extensively [10-12], was performed with a simple
noninvasive radial pulse wave recording and computer
analysis of the diastolic decay. This provides
separate assessment of the large artery or capacitive compliance
(C1) and small artery reflective or oscillatory
compliance (C2). Cardiac output and stroke volume were
computed from the average waveforms. Systemic vascular
resistance (SVR) is calculated as mean arterial pressure
(MAP) divided by cardiac output (CO). Arterial
elasticity was determined at the baseline visit and at the
3- and 6 -month on-treatment visits.
Arterial Elasticity MeasurementsArterial compliance measures were performed after anovernight fast and before blood sampling. Measures wereperformed between 8 and 10 AM, in a quiet, temperature-controlled laboratory. With the subject in a supine position,radial arterial waveforms were recorded for 30 sec.The pressure transducer amplifier system was connectedto a specially designed device (Model CR-2000, HypertensionDiagnostics Inc. Eagan, MN). The passive transientresponse of the arterial vasculature to the initialloading conditions was determined by analyzing the diastolicportion of the pressure pulse-wave form. This technique,which has been validated for its reproducibilityand used extensively [10-12], was performed with a simplenoninvasive radial pulse wave recording and computeranalysis of the diastolic decay. This providesseparate assessment of the large artery or capacitive compliance(C1) and small artery reflective or oscillatorycompliance (C2). Cardiac output and stroke volume werecomputed from the average waveforms. Systemic vascularresistance (SVR) is calculated as mean arterial pressure(MAP) divided by cardiac output (CO). Arterialelasticity was determined at the baseline visit and at the3- and 6 -month on-treatment visits.
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