Fertilizer application and weed control methods were compared to determine the best method for organic sugarcane production under supplemental irrigation at BSI farm. The experimental design was 2x5 factorial in RCB with 3 replications. The first factor was two sorts fertilizers as followers of fertilizer application, there being kinds BSI organic fertilizer at the rate of 200 kg/rai and chemical fertilizer (basal application with 15-15-15 at the rate of 50kg/rai). The second factor was 5 weed control methods which consisted of 1) intercropping with cowpea 2) hand weeding 3) cultivated by using rotary plow attached to small tractor (24 hp) 4) covered interrow of cane by using plastic and 5) herbicide application as farm practice. The results indicated that there were no difference in cane yield, sugar content and sugar yield between organic fertilizer and chemical fertilizer application. The additional advantage of weed control for organic sugarcane production was intercropping with cowpea increasing of soil organic matter. However, there were no significant differences in cane yield and sugar content amongst five weed control methods. Chemical fertilizer application can be replaced by BSI organic fertilizer at rate of 200 kg/rai, whereas herbicide application for controlling weed was replaced by intercropping with cowpea in organic sugarcane production. Keywords: Fertilizer, intercropping 1