4. Conclusions
In 1908, Claudius Regaud, a pioneer in radiotherapy and founder of the Curie Institute in Paris (France), stated: “C’est la chromatine nucléaire quiest la partiela plus sensible descellules” (“it’s nuclear chromatin that is the most sensible part of the cell”) (Vogin & Foray, 2013). More than a century after, we are still struggling tounderstand the precise link between chromatin architecture and dynamics and the effect of radiation. While everybody agrees that chromatin influences both the amount and location of breakages produced by IR as well as the efficiency of the repair process, the mechanisms are still misunderstood.New advances in the knowledge of chromatin organization and dynamics may be of high clinical interest: