Taenia solium taeniasis-cysticercosis and soil-transmitted helminths (STHs) are parasitic Neglected Trop-ical Diseases endemic throughout Southeast Asia. Within Lao PDR, a remote northern hill tribe villagehad previously been identified as a hyper endemic focus for T. solium. To reduce this observed prevalence,a One Health intervention covering both pigs and humans was implemented, which included two Massdrug administrations (MDA1 and MDA2) for village residents using a triple dose albendazole 400 mgtreatment regime. In addition to the effect on T. solium levels, the dual impact of this anthelmintic regimeon STHs within the community was also monitored.Faecal samples were collected pre and post MDA1 and MDA2 and analysed for the presence of Tae-nia species and the STHs Ascaris lumbricoides, Trichuris trichiura and hookworm species. The McMastertechnique was used to measure the changes in both prevalence and intensity of infection. Molecularcharacterisation of Taenia and hookworm species was conducted to detect zoonotic species.The level of taeniasis within the sampled population decreased by 79.4% after MDA1, remained steadyduring the five month inter-treatment interval and decreased again by 100% after MDA2. The prevalenceof STHs decreased by 65.5% and 62.8% after MDA1 and MDA2 respectively; however an increase to 62.1%of pre MDA1 levels was detected during the inter-treatment interval. Individually, hookworm prevalencedecreased by 83.4% (MDA1) and 84.5% (MDA2), A. lumbricoides by 95.6% and 93.5% and T. trichiura by 69.2%and 61%. The intensity of infection within the sampled population also decreased, with egg reduction ratesof 94.4% and 97.8% for hookworm, 99.4% and 99.3% for A. lumbricoides and 77.2% and 88.5% for T. trichiura.Molecular characterisation identified a T. solium tapeworm carrier from 21.6% (13/60) of households inthe village. T. saginata was identified in 5% (3/60) of households. The zoonotic hookworm A. ceylanicumwas detected in the resident dog population.These results suggest that the triple dose albendazole 400 mg treatment regime achieved a significantreduction in the level of taeniasis whilst simultaneously reducing the STH burden within the village.The increased STH prevalence detected between MDAs reflects the need for behavioural changes and asustained chemotherapy programme, which may also need to include the resident dog population.