Food for Thought
› Although individual studies on the effects of antidepressants on depression in patients with PD have produced positive results, authors of a 2011 systematic
review of 20 randomized trials comparing antidepressants to placebo in 1,137 adults with neurological disorders found no significant differences in patients
with PD (Price et al., 2011)
› In addition to potentially helping to alleviate depression in patients with PD, tricyclic antidepressants may also improve sialorrhea (i.e., excessive secretion of
saliva), a common complication of PD, because of their anticholinergic side effects