The genus Mentha L includes 18 species and about 11 hybrids, of which the most used and cultivated are Mentha spicata (spearmint) and the hybrid Mentha x piperita (pep¬permint). Mints are available in all five continents, are used in traditional medicine for the prevention and therapy of several diseases, and are a well-known herbal remedy used for their aromatic, stomachic, choleretic, carminative, and stimulant properties. The most active compounds in mints are the essential oil and polyphenols. The main phenolic compounds are phenolic acids and flavonoids [6,26,27]. Studies on the anti-diabetic effects of mint are scarce, despite their appreciable total phenolic content. Water extracts of peppermint have been shown to improve glyce¬mia and lipidemia in offspring of streptozotocin-induced diabetic rats [28]. Nevertheless, Narendhirakannan et al. [29] have shown that peppermint ethanolic extracts have no effect on insulin, C-peptide levels, and glucose tolerance in the same animal model.