Grape seed extract (GSE) was added as antioxidant in turkey and pork emulsions make with mechanically separated meat (MSM). The Antioxidant capacity (AC: ORACFL) and lipid oxidation (TBARS and lipid peroxides) were measured on control (C) and emulsion added 0.5% GSE before and after “in vitro” gastric digestion. Results showed that gastric digestion increased the AC of meat by 8–11-fold. Based on the data obtained, the incorporation of GSE at 0.5% to meat emulsions has shown to be adequate to prevent lipid oxidation and improve the AC of the emulsions; this effect was retained after simulated gastric digestion of the samples.