The characteristic negative symptoms of apathy, anhedonia
and amotivation are to be expected from the
diminishing reward system activity of hypofrontality
(Glassman 1993; Lyon 1999). Consistent with the theory
that these symptoms of schizophrenia arise in part, from
the dysfunction of mesolimbicocorticol dopamine cells and
would benefit from an increase in dopamine release,
smoking in schizophrenia may occur in an attempt to
reverse this dysfunction.