Introduction: Musculoskeletal complaints (MHC) in professional musicians are common but a lack of prospective studies in the field of music medicine, identification of causal relations in the etiology of musculoskeletal disorders in instrumental musicians is challenging. Objectives: A prospective cohort study was launched with 1) determining the prevalence of MHC among music students 2) to compare the physical and mental health of music students and non-music students at the start of the study 3) identify risk variables for MHC, and 4) develop an MHC prediction model in musicians. Methods: The measurements consisted of a self-designed questionnaire addressing history of pain, localization of pain, habits, practicing and sports, validated questionnaires measuring health related QuoL (SF12), stress symptoms (SCI), and performance anxiety (KMPAI) and physical examination including core stability, hypermobility, cervical range of motion, mechanosensitive. Occurrences (incidence and prevalence) of MHC were recorded monthly by online questionnaires. Results: 278 are included for the cross-sectional comparison and 149 for the longitudinal analysis so far. The monthly and yearly prevalence of MHC was 27% and 56% respectively. Yearly incidence rate was 29%. The number of stress symptoms and mechanosensitive were considerably increased (p