The microwave-assisted extraction (MAE) of 13 different green coffee beans (Coffea arabicaL.) was com-pared to Soxhlet extraction for oil obtention. The full factorial design applied to the microwave-assisted
extraction (MAE), related to time and temperature parameters, allowed to develop a powerful fast and
smooth methodology (10 min at 45C) compared to a 4 h Soxhlet extraction. The quantification of cafe-stol and kahweol diterpenes present in the coffee oil was monitored by HPLC/UV and showed satisfactory
linearity (R
2
= 0.9979), precision (CV 3.7%), recovery (<93%), limit of detection (0.0130 mg/mL), and limit
of quantification (0.0406 mg/mL). The space–time yield calculated on the diterpenes content for sample
AT1 (Arabica green coffee) showed a six times higher value compared to the traditional Soxhlet method
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