A class of fibrate drugs, long in use for therapeutic purposes, is believed to target the PPARα protein, accounting for the
ability of these molecules to reduce triglycerides and raise HDL lipids. This receptor
subtype also remains a major target for drug development for cardiovascular indications
(140, 141). More recently, PPARγ ligands are being evaluated for their therapeutic potential
in carcinogenesis and Alzheimer’s disease (142–147).