Nurses who practice in clinical research are often
the first to experience and work with research participants
on the actual delivery and management of a new
therapy, drug, or device. They may be the first to have
a hint of implications that later become important to
the general use of the new interventiondeither an
adverse event or a needed modification in delivery or
implementation that is important to patient tolerance
and adherence. Observations made by nurses who are
the agents of implementation in a clinical trial may
therefore have direct bearing on the speed with which
translation to the next level of testing and use can
occur.