Protocolized, quantitative resuscitation of patients with sepsis- induced tissue hypoperfusion (defined in this document as hypotension persisting after initial fluid challenge or blood lactate concentration ≥ 4 mmol/L) (grade 1C).
Goals during the first 6 hrs of resuscitation:
a) Central venous pr
essure (CVP) 8–12 mm Hg
b) Mean ar
terial pressure (MAP) ≥ 65 mm Hg
c) Urine output ≥ 0.5 mL/kg/hr
d)
Central venous (superior vena cava) or mixed venous oxygen saturation 70% or 65%, respectively
° In patients with elevated lactate levels targeting resuscitation to normalize lactate (grade 2C).