COLCHICINE - (Merck; Lilly)
Available as a tablet (contains 0.5 mg colchicine and 0.5 mg probenecid) for oral administration or as an injectable solution (0.5 mg/ml) for IV administration. Both colchicine and probenecid have anti-gout activity. Inhibits release of histamine-containing gran- ules from mast cells. Injectable solution used as an inhibitor of collagen production and may stimulate collagenase activity. May be indicated in some cases of hepatic fibrosis. Will not reverse fibrosis but may be helpful in preventing further damage.
May potentiate gout formation in some cases. Numerous metabolic side effects. Administration should be discontinued if vomiting or diarrhea occur.