In 2009, a genetically re-engineered measles virus, originally created as a cure for cancer, turns into a lethal strain which kills 90% of those it infects, and mutates the remaining 10% into predatory, nocturnal "Darkseekers" who are extremely vulnerable to sunlight and other sources of UV. Three years after the outbreak, US Army virologist Lieutenant Colonel Robert Neville (Will Smith) lives an isolated life in New York City, which is now deserted, unsure if any other uninfected humans are left in the world.
Neville's daily routine includes experimentation on infected rats to find a cure for the virus and trips through Manhattan to hunt for food and supplies. He also waits each day for a response to his continuous recorded radio broadcasts, which instruct any uninfected survivors to meet him at midday at the South Street Seaport. Flashbacks reveal that his wife (Salli Richardson) and daughter (Willow Smith) died in a helicopter accident during the chaotic evacuation of Manhattan, prior to the military-enforced quarantine of the island in 2009. Neville's loneliness is mitigated only by the companionship of his German Shepherd, Sam, interaction with mannequins he has set up as patrons at a video store, and recordings of old television broadcasts. At night, he barricades himself and Sam inside his heavily fortified Washington Square Park home to hide from the Darkseekers. One day while waiting for survivors, Sam follows a deer into a dark building while she and Robert were hunting. Neville cautiously goes in after her and finds the deer's corpse along with Sam, but the building is infested by a colony of Darkseekers, both manage to escape unharmed and the attacking Darkseekers are killed by the sunlight.
Neville finds a promising treatment derived from his own blood, so he sets a snare trap and captures a female Darkseeker while the alpha male Darkseeker watches from the shadows. Back in his laboratory in the basement of his house, Neville treats the female without success. The next day, he is ensnared in a trap similar to the one he used to capture the female, and by the time he manages to escape, it is dark and he is attacked by infected dogs. Sam and he manage to kill them, but Sam is bitten in the fight. Neville brings Sam home and injects her with a strand of his serum, but when she shows signs of infection and tries to attack him, Neville is forced to strangle her to death. The next night, driven over the edge by loneliness, he ventures out and suicidally attacks a group of Darkseekers. He is nearly killed, but is rescued by a pair of immune survivors, Anna (Alice Braga) and a young boy named Ethan (Charlie Tahan), who have traveled from Maryland after hearing one of his broadcasts. They take the injured Neville back to his home, where Anna explains that they survived the outbreak aboard a Red Cross evacuation ship from São Paulo and are making their way to a survivors' camp in Bethel, Vermont. Neville angrily argues that no such survivor's camp exists.
Neville once again attempts to administer a potential cure to the infected woman in his laboratory, but the next night, a group of Darkseekers, who had followed Anna and Neville back the night before, attacks the house and overruns its defenses. Neville, Anna, and Ethan retreat into the basement laboratory, sealing themselves in with the female Darkseeker on which Neville has been experimenting. Discovering that the last treatment was successful, Neville draws a vial of her blood and gives it to Anna, before shutting Ethan and her inside a coal chute in the back of the lab. He then takes a grenade and kills the Darkseekers and himself, saving the cure.
Alternate Ending
The alpha male makes a butterfly-shaped smear on the glass. Neville realizes that the alpha male is identifying the female upon which he was experimenting by a butterfly tattoo, and the alpha male wants her back. Neville puts his gun down and returns the female. Neville and the alpha male both stare each other down; Neville apologizes to the Darkseekers; the alpha male accepts his apology, and the Darkseekers leave. Shocked by the ordeal, Neville sits down for a moment in his laboratory. Looking over the pictures of his numerous test subjects, the implications of his research methods begin to dawn on him. The final shot follows Neville, Anna, and Ethan as they drive away towards the survivor's camp in Vermont with the antidote.
ในปี 2009 ไวรัสโรคหัดแปลงพันธุกรรมออกแบบใหม่ สร้างเป็นโรคสำหรับโรคมะเร็ง กลายเป็นต้องใช้ยุทธภัณฑ์ซึ่งฆ่า 90% ของผู้ติด และ mutates 10% ที่เหลือเป็นมหาศาล บรรณาธิการ "Darkseekers" ที่เสี่ยงมากที่จะแสงแดดและ UV แหล่งอื่น ๆ สามปีหลังจากการระบาดของโรค กองทัพเรา virologist พันโทโรเบิร์ตเนวิลล์ (วิลล์สมิธแสดง) ชีวิตมีชีวิตแยกในนิวยอร์ก ซึ่งตอนนี้ร้าง แน่ใจมนุษย์เชื้ออื่น ๆ ที่เหลือในโลกNeville's daily routine includes experimentation on infected rats to find a cure for the virus and trips through Manhattan to hunt for food and supplies. He also waits each day for a response to his continuous recorded radio broadcasts, which instruct any uninfected survivors to meet him at midday at the South Street Seaport. Flashbacks reveal that his wife (Salli Richardson) and daughter (Willow Smith) died in a helicopter accident during the chaotic evacuation of Manhattan, prior to the military-enforced quarantine of the island in 2009. Neville's loneliness is mitigated only by the companionship of his German Shepherd, Sam, interaction with mannequins he has set up as patrons at a video store, and recordings of old television broadcasts. At night, he barricades himself and Sam inside his heavily fortified Washington Square Park home to hide from the Darkseekers. One day while waiting for survivors, Sam follows a deer into a dark building while she and Robert were hunting. Neville cautiously goes in after her and finds the deer's corpse along with Sam, but the building is infested by a colony of Darkseekers, both manage to escape unharmed and the attacking Darkseekers are killed by the sunlight.Neville finds a promising treatment derived from his own blood, so he sets a snare trap and captures a female Darkseeker while the alpha male Darkseeker watches from the shadows. Back in his laboratory in the basement of his house, Neville treats the female without success. The next day, he is ensnared in a trap similar to the one he used to capture the female, and by the time he manages to escape, it is dark and he is attacked by infected dogs. Sam and he manage to kill them, but Sam is bitten in the fight. Neville brings Sam home and injects her with a strand of his serum, but when she shows signs of infection and tries to attack him, Neville is forced to strangle her to death. The next night, driven over the edge by loneliness, he ventures out and suicidally attacks a group of Darkseekers. He is nearly killed, but is rescued by a pair of immune survivors, Anna (Alice Braga) and a young boy named Ethan (Charlie Tahan), who have traveled from Maryland after hearing one of his broadcasts. They take the injured Neville back to his home, where Anna explains that they survived the outbreak aboard a Red Cross evacuation ship from São Paulo and are making their way to a survivors' camp in Bethel, Vermont. Neville angrily argues that no such survivor's camp exists.Neville once again attempts to administer a potential cure to the infected woman in his laboratory, but the next night, a group of Darkseekers, who had followed Anna and Neville back the night before, attacks the house and overruns its defenses. Neville, Anna, and Ethan retreat into the basement laboratory, sealing themselves in with the female Darkseeker on which Neville has been experimenting. Discovering that the last treatment was successful, Neville draws a vial of her blood and gives it to Anna, before shutting Ethan and her inside a coal chute in the back of the lab. He then takes a grenade and kills the Darkseekers and himself, saving the cure.Alternate Ending The alpha male makes a butterfly-shaped smear on the glass. Neville realizes that the alpha male is identifying the female upon which he was experimenting by a butterfly tattoo, and the alpha male wants her back. Neville puts his gun down and returns the female. Neville and the alpha male both stare each other down; Neville apologizes to the Darkseekers; the alpha male accepts his apology, and the Darkseekers leave. Shocked by the ordeal, Neville sits down for a moment in his laboratory. Looking over the pictures of his numerous test subjects, the implications of his research methods begin to dawn on him. The final shot follows Neville, Anna, and Ethan as they drive away towards the survivor's camp in Vermont with the antidote.
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