Gutfungiareabletoproduceasubstantialmassofnatural productsknownasfungalmetabolites.Somefungalmetabolitesareharmfulandcausevariousintestinaldiseases,or causeextraintestinaldiseasebyimpairingtheintestinalbarrier.Incontrast,somefungalmetabolitesarevaluablesources ofdrugs.Herewedescribetheroleofseveralfungalmetabolitesinhumanmetabolicdiseases(Fig.1).