In the present study, the levels of both SOD and CAT activities of tissues of diabetic group were therefore,
significantly increased on treatment with drumstick leaves for 21 days. The diminished SOD and CAT activities in the
diabetic control group were regenerated. Decreased levels of SOD and CAT in diabetic state may be due to inactivation
caused by ROS. In treated group, the increased CAT activity could be due to higher production of H2O2. It is possible
that CAT activity, which would protect SOD inactivation by H2O2, causes an increase in SOD activity. Increase in SOD
would protect CAT against inactivation by superoxide anion. Superoxides are important in the ischemic tissue injury
commonly associated with diabetic microangiopathy[32] and as potential initiators of the chain reactions that can produce
hydrogen peroxide.