Bacteria can be classified based on their biochemical and microbiological properties as well as their morphology. These classification criteria are well known in the art. In general the mycoplasma infection is associated with the clinical signs described elsewhere in this description.Reducing in the incidence of or the severity of clinical signs caused by or being associated with the particular mycoplasma infection in a subject can be reached by the administration of one or more doses of the immunogenic composition of the present invention to a subject in need. As demonstrated by the Examples 2 and 3, the immunogenic composition as provided herein has been proven to be efficacious after the administration of a single dose to a subject of need.