Synopsis
A cosmetic patch containing tamarind fruit extract was formulated and developed by blending two types of natural polymers: chitosan with molecular weight of100 000 and starch suchas corn, potato ortapioca starch. The physicochemical characteristics, i.e. £ex- ibility, colour, transparency, integrity, gloss, water sorption and bioadhesion property and the stability of the patch without tamarind content were investi- gated. Stability test was performed by keeping the prepared patches at 4 8C, at room temperature or at 45 8C for 2 weeks.Theresults showed that theformu- lations composed of chitosan:corn starch ratio of 4.5 : 0.5 (CC4.5 : 0.5) and chitosan:tapioca starch ratios of 4.5 : 0.5 (CT4.5 : 0.5)and4.0:1.0(CT4:1)provide patches with favourable physical characteristics, high water sorption, good bioadhesion ability and good stability. After the lyophilized tamarind extract in an amount corresponding to 5% of tartaric acid was incorporated into the formulations of CC4.5 : 0.5, CT4.5 : 0.5 and CT4:1, the ability of the patches to adhere to skin was improved. However, after keeping the test patches at room temperature or at 45 8Cfor 6 weeks, their colours were intensi¢ed while their £exibilities and skin adhesion properties decreased. A12-h in vitro permeation was investigated by studying the cumulative amount of tartaric acid
Synopsis
A cosmetic patch containing tamarind fruit extract was formulated and developed by blending two types of natural polymers: chitosan with molecular weight of100 000 and starch suchas corn, potato ortapioca starch. The physicochemical characteristics, i.e. £ex- ibility, colour, transparency, integrity, gloss, water sorption and bioadhesion property and the stability of the patch without tamarind content were investi- gated. Stability test was performed by keeping the prepared patches at 4 8C, at room temperature or at 45 8C for 2 weeks.Theresults showed that theformu- lations composed of chitosan:corn starch ratio of 4.5 : 0.5 (CC4.5 : 0.5) and chitosan:tapioca starch ratios of 4.5 : 0.5 (CT4.5 : 0.5)and4.0:1.0(CT4:1)provide patches with favourable physical characteristics, high water sorption, good bioadhesion ability and good stability. After the lyophilized tamarind extract in an amount corresponding to 5% of tartaric acid was incorporated into the formulations of CC4.5 : 0.5, CT4.5 : 0.5 and CT4:1, the ability of the patches to adhere to skin was improved. However, after keeping the test patches at room temperature or at 45 8Cfor 6 weeks, their colours were intensi¢ed while their £exibilities and skin adhesion properties decreased. A12-h in vitro permeation was investigated by studying the cumulative amount of tartaric acid
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