Although the rate of hepatotoxicity occurring later than 7 days was significantly lower in patients receiving RT than in those receiving DT (8.1% vs. 21.4%, p = .001), the occurrence rate of early onset hepatotoxicity (≤7 days) was similar (13.4% in the RT group vs. 15.4% in the DT group, p = .376), indicating that early-onset adverse effects could not be prevented even with RT.