For this purpose, seventy-five day-old chicks were randomly divided into five equal groups (15 each). G1, kept as control negative; G2, infected non treated (control positive); G3, infected treated with toltrazuril (1 mL/L); G4, infected treated with sodium sulfaclozine (2 mL/L); G5, infected treated with toltrazuril (1 mL/L) + sulfaclozine Na (2 g/L).Was performed to investigate The theraputic efficacy and collected sample findings of the cecal, hepatic, and renal tissues for histopathology