distinguished for their
immunomodulatory actions and therapeutic applications
Despite the uncertainty in the underlining molecular mechanisms,
recent evidence suggests that L. plantarum secretes immunomodulatory agents that alter immunological signaling cascades.
Here, we present the metabolomic shifts
revealed by principal component analysis that correspond to the mid-log-stationary transition of L. plantarum, and identify
pyroglutamic (pyro) dipeptides within this transition as correlative with the immunomodulatory actions