The
STZ-induced diabetic male Sprague-Dawley rats fed the Agaricus bisporus powder (ABP; 200
mg/kg of body weight) for 3 weeks had significantly reduced plasma glucose and triglyceride (TG)
concentrations (24.7% and 39.1%, respectively), liver enzyme activities, alanine aminotransferase
and aspartate aminotransferase (11.7% and 15.7%, respectively), and liver weight gain (P b .05). In
hypercholesterolemic rats, oral feeding of ABP for 4 weeks resulted in a significant decrease in
plasma total cholesterol (TC) and low-density lipoprotein (LDL) (22.8% and 33.1%, respectively)
(P b .05). A similar significant decrease in hepatic cholesterol and TG concentrations was observed
(36.2% and 20.8%, respectively) (P b .05).