A first-generation cephalosporin such as cefazolin 1 g should be administered intravenously to reduce the risk of infection at the insertion site (see the image below).[6] If the patient is allergic to penicillin, an alternate antibiotic can be given for gram-positive coverage. If the patient is already taking antibiotics for another indication, additional antibiotics are not needed (but broad-spectrum gram-positive coverage should be ensured).