Preload with glucomannan decreased ghrelin concentrations to the lowest percentage at 2 h, though with no statistical
difference when compared with white rice preload or glucose load alone.
Interestingly, when subjects were separated into tertiles by HOMA-IR values, prandial ghrelin reduction in the glucomannan-primed of the middle tertile was greater than in the placebo-primed ( p = .03).
Leptin significantly decreased with nadir at 2 h after preload with glucomannan but not with placebo or in an unprimed
condition.