Some islet cells underwent changes in the size and shrunk.
A decrease in the number of islet cells also occurred in comparison to those of control rats (Fig. 3b).
An improvement of diabetic rat islets is observed after treatment with andrographolide (4.5 mg kg-1 b.wt) and glibenclamide for 8 days (Fig. 3c and d).
However, treatment with andrographolide-enriched extract of A. paniculata exhibited moderate improvement of diabetic rat islets (Fig. 3e).