Similarly, receptor-specific
peptides improved their ability to induce angiogenesis when conjugated to a nanoparticle surface
(6). Presentation of the peptide on a structured scaffold increased angiogenesis, which is dependent
on receptor-mediated signaling. These findings highlight the advantages of having a ligand
bound to a nanoparticle as opposed to its being free in solution. The nanoparticle surface creates a
region of highly concentrated ligand, which increases avidity and, potentially, alters cell signaling.
However, this benefit comes at a cost: Nanomaterials can also cause unexpected changes in
Similarly, receptor-specificpeptides improved their ability to induce angiogenesis when conjugated to a nanoparticle surface(6). Presentation of the peptide on a structured scaffold increased angiogenesis, which is dependenton receptor-mediated signaling. These findings highlight the advantages of having a ligandbound to a nanoparticle as opposed to its being free in solution. The nanoparticle surface creates aregion of highly concentrated ligand, which increases avidity and, potentially, alters cell signaling.However, this benefit comes at a cost: Nanomaterials can also cause unexpected changes in
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