An extensive Monte Carlo (MC) study shows that the proposed technique provides a well-controlled Type I error rate, as well as very accurate CI estimation, that outperforms the CI estimation based on the classical schemes to analyze the PWMs.
These results are clearly observed in the cases when underlying data are skewed and/or consist of a relatively small number of data points.
A real data example of myocardial infarction disease is used to illustrate the applicability of the proposed method.