The principal objective of an extraction process is to maximize
the target-compound yield with no or minimal impact on properties
of the target compound whilst minimizing the extraction of
undesirable compounds. Conventional solid-liquid extraction (SLE)
techniques, including maceration, infusion and “Soxhlet” extraction,
are time consuming and use large amounts of solvents [1].
Several chlorinated solvents (e.g., chloroform, carbon tetrachloride,
tetrachloroethylene, and chlorobenzene) and non-chlorinated
solvents (e.g., acetone, methanol, and acetonitrile) are used for extraction
from various matrices, depending on the properties of the
target compound. Safety risks, toxicity of certain solvents and