In this paper, we use SEIR model based on Olaniyi and Obabiyi [9] and Shah and Gupta [12], and apply it to malaria transmission between mosquitoes and humans. We assume that recovered human individuals can enter into the susceptible class again, mosquitoes never enter the recovered class and the newborn’s birth with infection can enter I compartment. We determine the stability analysis of the disease – free and endemic equilibria. The rest of the paper is organized as follows: In section 2, we present the SEIR model description and derived the basic reproduction number. Model analysis consisting of the stability analysis of disease-free and endemic equilibria is discussed in section 3. In section 4 we apply the SEIR model to malaria