A majority of the glucose-reducing agents available for the treatment of diabetes mellitus consists of agents which improve insulin production by β cells. Here it was shown that G. procumbens was able to lower blood glucose without affecting plasma insulin levels. Therefore, it was likely that the hypoglycemic action of the fractions observed could be due to direct or indirect effects on the activities of one or more of the upstream components of the insulin biosignaling pathway. Thus, isolation and purification efforts towards identification of the active principle in the G. procumbens fractions responsible for these activities as well as determination of upstream kinases involved are pertinent.