Sepsis represents a continuum of illness due to systemic inflammation caused by an infection that requires prompt recognition and treatment. While sepsis is a significant
cause of death worldwide, its mortality is believed to be disproportionately high in low- and middle-income countries (LMICs). Since 1992, its definition has
become standardized, and beginning in 2002, an international collaboration has produced a set of consensus guidelines on the optimal management of septic patients.
Based on new evidence, significant updates have been made since then. It is known that application of a bundled approach to patient care with the use of specific resuscitation
endpoints to guide therapy leads to significant reductions in mortality from sepsis. However, it is also recognized that the implementation of such interventions
in LMICs is extremely challenging. Consequently, a body of literature on practical guidelines for sepsis in developing countries has emerged. This article provides a
review of the evidence for the best practice of sepsis management, with recommendations for resource-limited settings.
Sepsis represents a continuum of illness due to systemic inflammation caused by an infection that requires prompt recognition and treatment. While sepsis is a significantcause of death worldwide, its mortality is believed to be disproportionately high in low- and middle-income countries (LMICs). Since 1992, its definition hasbecome standardized, and beginning in 2002, an international collaboration has produced a set of consensus guidelines on the optimal management of septic patients.Based on new evidence, significant updates have been made since then. It is known that application of a bundled approach to patient care with the use of specific resuscitationendpoints to guide therapy leads to significant reductions in mortality from sepsis. However, it is also recognized that the implementation of such interventionsin LMICs is extremely challenging. Consequently, a body of literature on practical guidelines for sepsis in developing countries has emerged. This article provides areview of the evidence for the best practice of sepsis management, with recommendations for resource-limited settings.
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