Some adults receiving oseltamivir (tamiflu) have also reported nausea and vomiting (Ryan, Ticehurst, & Dempsey, 1995). Furthermore, high-level drug resistance is associated with both inhibitors. In 2009, oseltamivir-resistant H1N1 viruses arose spontaneously and spread globally. This resistance was conferred by a single amino acid change in the viral neuraminidase (H274Y) (Hurt, Holien, Parker, & Barr, 2009). Therefore, continuous research for new antiviral compounds from natural products is needed to develop new therapeutic agents in the battle against the influenza viruses (De Clercq, 2006).