A 73-year-old male with a history of palliative choledochojejunostomy for unresectable pancreatic adenocarcinoma 8 years prior presented to our emergency department with a 2-day history of vague abdominal pain, malaise and subjective fevers. Laboratory testing demonstrated an elevated white blood cell count of 13.9 × 103/μL (reference range 3.7 - 8.4 × 103/μL) and normal liver function tests and chemistry panel. As part of his diagnostic workup, a CT scan of the abdomen and pelvis was obtained, which demonstrated diffuse thickening of the hepaticobiliary limb concerning for a functional afferent limb syndrome due to bacterial overgrowth (Fig. 1). The patient was admitted to the surgical care unit and treated with a course of levaquin and flagyl. His symptoms and leukocytosis quickly resolved and he was discharged to home on hospital day 2.